A GPCR Handles Bacterial Sensing in Chemotaxis and Phagocytosis
نویسندگان
چکیده
منابع مشابه
Quantification of Live Bacterial Sensing for Chemotaxis and Phagocytosis and of Macropinocytosis
Initial immunological defense mechanisms to pathogen invasion rely on innate pathways of chemotaxis and phagocytosis, original to ancient phagocytes. Although chemotaxis has been well-studied in mammalian and model systems using purified chemoattractants in defined conditions, directed movement toward live bacteria has been more difficult to assess. Dictyostelium discoideum is a professional ph...
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Chemotaxis models are based on spatial or temporal gradient measurements by individual organisms. The key contribution of Keller and Segel (J Theor Biol 30:225-234, 1971a; J Theor Biol 30:235-248, 1971b) is showing that erratic measurements of individuals may result in an accurate chemotaxis phenomenon as a group. In this paper we provide another option to understand chemotactic behavior when i...
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RpkA (Receptor phosphatidylinositol kinase A) is an unusual seven-helix transmembrane protein of Dictyostelium discoideum with a G protein coupled receptor (GPCR) signature and a C-terminal lipid kinase domain (GPCR-PIPK) predicted as a phosphatidylinositol-4-phosphate 5-kinase. RpkA-homologs are present in all so far sequenced Dictyostelidae as well as in several other lower eukaryotes like th...
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Chemotaxis is the directed motion of an organism toward environmental conditions it deems attractive and/or away from surroundings it finds repellent. Movement of flagellated bacteria such as Escherichia coli can be characterized as a sequence of smooth-swimming runs punctuated by intermittent tumbles. Tumbles last only a fraction of a second, which is sufficient to effectively randomize the di...
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INTRODUCTION Mononuclear phagocytes play a critical role during Alzheimer's disease (AD) pathogenesis due to their contribution to innate immune responses and amyloid beta (Aβ) clearance mechanisms. METHODS Blood-derived monocytes (BDMs) and monocyte-derived macrophages (MDMs) were isolated from blood of AD, mild cognitive impairment (MCI) patients, and age-matched healthy controls for molecu...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2016
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2016.02.006